Exosomes derived from M2 macrophages prevent steroid-induced osteonecrosis of the femoral head by modulating inflammation, promoting bone formation and inhibiting bone resorption

Exosomes derived from M2 macrophages prevent steroid-induced osteonecrosis of the femoral head by modulating inflammation, promoting bone formation and inhibiting bone resorption

Blog Article

Abstract Inflammatory reactions are involved in the development of steroid-induced osteonecrosis of the femoral head(ONFH).Studies have explored the therapeutic efficacy of inhibiting inflammatory reactions in steroid-induced ONFH and revealed that inhibiting inflammation may be a new strategy for preventing the development of steroid-induced ONFH.Exosomes derived from M2 macrophages(M2-Exos) display anti-inflammatory properties.This study aimed to examine chervo jacke herren the preventive effect of M2-Exos on early-stage steroid-induced ONFH and explore the underlying mechanisms involved.

In vitro, we explored the effect of M2-Exos on the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells(BMMSCs).In vivo, we investigated the role of M2-Exos on inflammation, osteoclastogenesis, osteogenesis and angiogenesis in an early-stage rat model of steroid-induced ONFH.We found that M2-Exos promoted the proliferation and osteogenic differentiation of BMMSCs.Additionally, M2-Exos effectively attenuated the osteonecrotic changes, inhibited the expression of proinflammatory mediators, promoted osteogenesis and angiogenesis, reduced osteoclastogenesis, and regulated the polarization of M1/M2 macrophages click here in steroid-induced ONFH.

Taken together, our data suggest that M2-Exos are effective at preventing steroid-induced ONFH.These findings may be helpful for providing a potential strategy to prevent the development of steroid-induced ONFH.